Cortexiphan

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[edit] Overview

Cortexiphan is a drug created by Doctor William Bell in 1981.
Re-testing Cortexiphan
According to Nina Sharp (Ability), Bell theorized that at birth, the human mind is infinitely capable, but each force that it encounters (social, physical, intellectual) begins a process he called "limitation" - a diminishing of that potential. Cortexiphan was designed in hopes of limiting this "limitation", preventing the natural shrinking of brainpower, resulting in people with increased mental ability. Due to the fact that Cortexiphan only prevented the limitation of the mind's potential rather than reversing it, it had to be administered to young children (whose potential had not yet been limited) in order to produce any results.
Walter Bishop states (Bad Dreams) that Cortexiphan works by enhancing people's abilities of perception. He explains that reality is the way we perceive the world around us. Therefore, by changing our perception, we change our reality. However, while normal people can only change their perception, Cortexiphan-positives can change other people's perceptions as well, thereby changing reality. Nick Lane is an example of this. When his moods changed, his perception changed, and therefore his reality changed. But he unwittingly also caused a change in perception of those around him. In other words, his moods were contagious, like a reverse-empath. It is also possible this is how Olivia Dunham was able to defuse David Robert Jones's bomb (Ability).
 Cortexiphan induces different abilities among test subjects. Olivia developed a psychic link with her test partner Nick Lane. In 1982, a 3-year-old Olivia appears to cause an "incident" in Walter and William Bell's lab causing a large portion of her room to appear charred or burned. According to Walter, this happened because Olivia was triggered when she became upset (Ability). In The Road Not Taken, Cortexiphan subject Susan Pratt grows agitated, then self-immolates when she is unable to control her pyrokinetic abilities. Her identical twin sister Nancy Lewis, who also had been part of the Jacksonville Cortexiphan trials, was triggered by extreme emotions but able to focus her pyrokinetic ability on Sanford Harris with coaching from Olivia Dunham. In Olivia. In The Lab. With The Revolver., terminally-ill James Heath, who is suffering from cancer, is able to exchange energy with his Cortexiphan-tested peer, just by touching them. This enabled Heath's condition to improve for a short period of time. His sister Julie visited him at the hospital, collapsed and died. After Heath visited Lloyd Becker, Miranda Greene, Alan DeRosa and Timothy Ober, each died within minutes of contact with him from aggressive cancer tumors. Heath was captured after he attempted to contact Olivia. In Concentrate And Ask Again, the science team asked Simon Phillips, an undocumented Cortexiphan test subject from the Wooster Trials, to read the mind of unconscious bed-ridden Downey and identify two other suspects - Dillon and Vannoy. In the adjusted Season 4 timelinw, Walter recalled Subject 9 who after been treated with Cortexiphan able to perform astral projection, creating distortion in the magneic field and attract metallic objects. Subject 9 is Cameron James. He claimed that he never been able to astral project after the Cortexiphan trial ended; however, the bad side effects of able to uncontrolled telekinetically move metals when he is not calm. He later helped the Fringe Division to displaced the energy following Olivia.
 Cortexiphan test subjects could be immune to each other's ability. Simon Phillips was not able to read Olivia's mind (Concentrate And Ask Again). Young Nick Lane was not burned by young Olivia's pyrokinetic outburst (Subject 13).
 Cortexiphan-positives must be activated in order to use their abilities. David Robert Jones used the first test of the evaluation system to try and activate Olivia Dunham. Similar test item was found in Nick Lane's drawer (Bad Dreams) and in the room where Nancy Lewis was held as a prisoner (The Road Not Taken). Nick Lane mentioned to Olivia that he was visited by a "strange man with the glasses", who is presumably responsible for activating him. James Heath also claimed that he was visited by an unidentified man, who told him he could learn to control his cancer because of testing done on him as a child in Jacksonville.
 At the conclusion of Bad Dreams, Nick Lane is seen in a drug-induced coma in an unidentified facility. James Heath is also seen in a drug induced coma in an unidentified facility at the end of Olivia. In The Lab. With The Revolver.. The coma has arrested the progression of Heath's cancer.
 In Over There, Part 1, James Heath, Nick Lane and Sally Clark successfully gain control and repurpose their abilities through the help of Massive Dynamic's series of experiments. Together with Olivia Dunham, their collective psychic energy allowed them to cross over to the alternate universe. This, however, seems to affected the Cortexiphan subjects except for Olivia. They are unable to control their abilities. James Heath dies because of his rapid-onset disease. Later, in an encounter with the Fringe Division of the other side, Nick Lane is shot by Lincoln Lee and Sally Clark uses her pyrokinetic ability, causing herself and Nick Lane to vanish, while leaving Lincoln Lee with third degree burns over most of his body.
 At the conclusion of Amber 31422, Secretary Bishop and Brandon Fayette monitor Olivia during her immersion in the sensory-deprivation tank in the lab on Liberty Island. They notice that her brain chemistry has spiked, and identify the dormant synthetic compound bound to her neurons. The estimate is that it has been there since she was a child. The two scientists do not recognize it as Cortexiphan, or a similar chemical compound from their universe.
 Testing continued through the Spring of 1986 (Subject 13) and Olivia crossed-over to the parallel universe several times. A combination of love and terror is attributed to inducing her ability. While fleeing her abusive father for violating a bedtime directive, seven year-old Olivia transitions to a large forested field. When she returns, her father strikes her in the face, in the hallway she returned to. The next night, upset that she was being denied access to Walter, Olivia rushes into his office to share her earlier discovery that she transited universes. In her emotional state, she transits into Secretary Bishop's office in the parallel universe and unwittingly reveals her secret to him, and that Peter is alive and well. She transits back when her Doctor Walter appears at the door to the office. Olivia also projected another kinetic outburst into the room she was isolated in for testing. Walter had tried several stressors to determine which would induce Olivia's ability. In the final test, Walter extinguished the lights in the locked room to terrify Olivia, then had her matched testing partner, Nick Lane, sneak onto the floor with injuries and pretending to have died. The stressful imagery caused Olivia's pyrokinetic outburst and scorched the room much like it did in 1982, when she was just three years-old.

[edit] Testing of Cortexiphan

 Two clinical trials testing the effect of Cortexiphan on humans took place in the mid-1980's, after earlier testing of the effect of the drug on animals. During these trials, children were paired together for companionship. The larger trial was performed on the Wooster Campus of Ohio State University. The smaller trial was held at a daycare facility on/near a military installation in Jacksonville, Florida. Olivia was a test subject in Jacksonville and was paired with Nick Lane. They were subjected to Cortexiphan dosing at very young ages. A spinal tap administered to Olivia by Mitchell Loeb (Bound) identified her Cortexiphan testing to David Jones. Broyles tells Nina (Olivia. In The Lab. With The Revolver.) that nearly a dozen Jacksonville test subjects and thirty Wooster test subjects remain unaccounted for. Olivia allowed Walter to readminister the drug (Jacksonville) to her to determine if she had any residual, or latent, abilities. The Massive Dynamic Experimental Campus (Over There, Part 1) houses many of the known Cortexiphan test subjects that still live. Initial rehabilitation efforts by Massive Dynamic appear successful.
  Cortexiphan can generate multiple advanced cognitive skills and telekinetic powers, depending on the individual involved. However, in Brave New World, Part 1, a small lemon cake, laced with pig brain DNA, was treated with the drug and responded with a 'regenerative' chemical and physical reaction. The cake self-sealed after the forensic experiment left it with a large incision across its' surface. The action was not related to any individual, their cognitive skills, or an associated kinetic projection.

[edit] Confirmed Test Subjects

Name Seen In Comments               
Olive D.
Olivia Dunham All Episodes • Listed on the daycare wall (Jacksonville) and in her notes (Olivia. In The Lab. With The Revolver.) as Olive D..
• Abducted, as an adult, and tested for Cortexiphan (Bound) via spinal tap. Results were positive.
• Sees a glimmer around objects from the alternate universe when she gets emotional.
• Generated a pyrokinetic event when she was a young Cortexiphan test subject.
• Uses her Cortexiphan-induced abilities to travel back and forth between local universes.
Nancy L.
Nancy Lewis The Road Not Taken • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Abducted and restrained to test her ability to control her pyrokinetic skills
• Used her Cortexiphan-induced pyrokinetic skills to kill Sanford Harris, saving her and Olivia's life.
• Her twin sister is Susan Pratt.
Susan L.
Susan Pratt The Road Not Taken • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.) as Susan L (Lewis).
• Died from self-induced combustion from the uncontrollable pyrokinetic skills she developed from Cortexiphan.
• Her twin sister is Nancy Lewis.
Nick L.
Nick Lane Bad Dreams
Over There, Part 1
Worlds Apart
• Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• His pairing with Olivia during Cortexiphan testing created a long lived psychic bond between the two.
• His psychic influence allowed him to live vicariously through the malicious acts he forced others to perform.
• His recovery has left him good-natured and an informal leader among other Cortexiphan recoverees.
• Sides with David Jones in the Season 4 timeline to generate seismic harmonics between the two universes.
Sally Clark
Sally Clark Over There, Part 1

Worlds Apart
• Was not listed as a member of the Jacksonville daycare test group
• Allowed Nick Lane to psychically guide her emotions during a romantic evening together.
• Vanished with the injured Nick Lane after nearly incinerating Lincoln Lee with her pyrokinetic abilities..
• Sides with David Jones in the Season 4 timeline to generate seismic harmonics between the two universes.
James H.
James Heath Olivia. In The Lab. With The Revolver.

Over There, Part 1
• Attempted to abate his aggressive cancer by swapping "energies" with other Cortexiphan children, killing them in the process.
• Failed when he attempted to swap "energy" with Olivia.
• Died almost immediately from cancer after arriving in the alternate universe.
• Brother of Julie Heath, who he inadvertently killed with his Cortexiphan-induced abilities.
Miranda G.
Miranda Greene Olivia. In The Lab. With The Revolver. • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Located by James Heath to absorb his aggressive cancer, she is now deceased.
• Heath also used her to locate other Cortexiphan test subjects.
Simon Phillips
Simon Phillips Concentrate And Ask Again • Developed the ability to read minds at the age of ten. Older than Olivia, he was not listed as her classmate in Jacksonville, but is familiar with her.
• Lived as a recluse in upstate New Hampshire because of the headaches he developed around others.
• Assisted the Fringe Team in hearing Aaron Downey’s thoughts to prevent an assassination attempt as it was happening.
Cameron James
Cameron James Subject 9 • The first Cortexiphan test subject, after Olivia, identified in the adjusted Season 4 timeline.
• Has the ability to telekinetically manipulate metal objects.
• Uses the alias 'Mark Little' to distance himself from his father, who used his post-Cortexiphan Trial trust fund to abuse drugs.
• Attempted to dissipate ethereal Peter Bishop when he was a trans-dimensional energy field causing damage.
Lloyd B.
Lloyd Becker Olivia. In The Lab. With The Revolver. • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Located by James Heath. Absorbed his aggressive cancer, he is now deceased.
Alan D.
Alan DeRosa Olivia. In The Lab. With The Revolver.
(photo only)
• Located by James Heath to absorb his aggressive cancer, he is now deceased.
Julie H.
Julie Heath Olivia. In The Lab. With The Revolver.
(photo only)
• Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Collapsed and died while visiting her brother, James Heath, while he was being treated for cancer.
Timothy O.
Timothy Michael Ober Olivia. In The Lab. With The Revolver.
(photo only)
• Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Located by James Heath to absorb his aggressive cancer, he is now deceased.
• Olivia remembers him after studying photos pinned on the wall.
Lisa B.
Lisa B. • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Nothing else is known.
Tessa E.
Tessa E. • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Nothing else is known.
Rich N.
Rich N. • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Nothing else is known.
Annie P.
Annie P. • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Nothing else is known.
Ken T.
Ken T. • Listed on the daycare wall (Jacksonville) and in Olivia's notes (Olivia. In The Lab. With The Revolver.).
• Nothing else is known.
Additional names from conversational dialogue.
- Jen, Ben. (Subject 13)


—   Plot Relevant Questions   — Address theories about questions on Cortexiphan/Theories   Ask minor questions on the Talk Page  

 1) Do not answer the questions here.
 2) Keep the questions open-ended and neutral: do not suggest an answer.

  • How did Walter and William Bell know to start preparing children for a "war" before Walter initiated the Zero Event in 1985?
  • Where are the rest of the Jacksonville children?
  • How many other test subjects are there?
  • What additional abilities do the other subjects have?
  • Why are the test subjects only recently discovering the effects of the drug?
  • Can the drug be passed on in the case of a pregnancy?
  • Were all the children in the daycare center subjected to Walter's experimentation?
  • Were the parents aware of Walter's experimentation on their kids?

Transcripts

Season 5 : Transilience Thought Unifier Model-11In AbsentiaThe RecordistThe Bullet That Saved The WorldAn Origin StoryThrough The Looking Glass And What Walter Found ThereFive-Twenty-TenThe Human KindBlack BlotterAnomaly XB-6783746The Boy Must LiveLibertyAn Enemy Of FateSeason 4 : Neither Here Nor ThereOne Night In OctoberAlone In The WorldSubject 9NovationAnd Those We've Left BehindWallflowerBack To Where You've Never BeenEnemy Of My EnemyForced PerspectiveMaking AngelsWelcome To WestfieldA Better Human BeingThe End Of All ThingsA Short Story About LoveNothing As It SeemsEverything In Its Right PlaceThe ConsultantLetters Of TransitWorlds ApartBrave New World, Part 1Brave New World, Part 2Season 3 : OliviaThe BoxThe PlateauDo Shapeshifters Dream Of Electric Sheep?Amber 314226955 kHzThe AbductedEntradaMarionetteThe FireflyReciprocityConcentrate And Ask AgainImmortality6BSubject 13OsStowawayBloodlineLysergic Acid Diethylamide6:02 AM ESTThe Last Sam WeissThe Day We DiedSeason 2 : A New Day In The Old TownNight Of Desirable ObjectsFractureMomentum DeferredDream LogicEarthlingOf Human ActionAugustSnakeheadGrey MattersUnearthedJohari WindowWhat Lies BelowThe Bishop RevivalJacksonvillePeterOlivia. In The Lab. With The Revolver.White TulipThe Man From The Other SideBrown BettyNorthwest PassageOver There, Part 1Over There, Part 2Season 1 : PilotThe Same Old StoryThe Ghost NetworkThe ArrivalPower HungryThe CureIn Which We Meet Mr. JonesThe EquationThe DreamscapeSafeBoundThe No-BrainerThe TransformationAbilityInner ChildUnleashedBad DreamsMidnightThe Road Not TakenThere's More Than One Of Everything